Recombinant diphtheria toxin derivatives: Perspectives of application
Identifieur interne : 002327 ( Main/Exploration ); précédent : 002326; suivant : 002328Recombinant diphtheria toxin derivatives: Perspectives of application
Auteurs : S. I. Romaniuk [Ukraine] ; D. V. Kolybo [Ukraine] ; S. V. Komisarenko [Ukraine]Source :
- Russian Journal of Bioorganic Chemistry [ 1068-1620 ] ; 2012-11-01.
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Abstract
Abstract: Diphtheria toxin (DT) is a unique bacterial protein which consists of three domains with various biological functions. Using genetic engineering for the creation of various recombinant constructions of DT with definite features, it is possible to create unique tools for cellular biology and toxins with efficient and selective action on certain populations of cells. The review highlights the structural and functional aspects of the DT molecule, its fragments and domains, as well as the major areas of application of its recombinant derivatives. In particular, the perspectives for practical use of recombinant DT derivatives are discussed for creating immunobiological preparations, cytotoxins, blockers of the heparin-binding epidermal growth factor-like growth factor (HB-EGF), protein constructions for direct delivery of substances into the cell, and also the possibility to use DT recombinant derivatives for therapy and prevention of a number of diseases.
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DOI: 10.1134/S106816201206012X
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I." last="Romaniuk">S. I. Romaniuk</name><affiliation wicri:level="1"><country xml:lang="fr">Ukraine</country><wicri:regionArea>Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv</wicri:regionArea><wicri:noRegion>Kyiv</wicri:noRegion></affiliation><affiliation></affiliation></author><author><name sortKey="Kolybo, D V" sort="Kolybo, D V" uniqKey="Kolybo D" first="D. V." last="Kolybo">D. V. Kolybo</name><affiliation wicri:level="1"><country xml:lang="fr">Ukraine</country><wicri:regionArea>Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv</wicri:regionArea><wicri:noRegion>Kyiv</wicri:noRegion></affiliation></author><author><name sortKey="Komisarenko, S V" sort="Komisarenko, S V" uniqKey="Komisarenko S" first="S. V." last="Komisarenko">S. V. Komisarenko</name><affiliation wicri:level="1"><country xml:lang="fr">Ukraine</country><wicri:regionArea>Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv</wicri:regionArea><wicri:noRegion>Kyiv</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Russian Journal of Bioorganic Chemistry</title><title level="j" type="abbrev">Russ J Bioorg Chem</title><idno type="ISSN">1068-1620</idno><idno type="eISSN">1608-330X</idno><imprint><publisher>SP MAIK Nauka/Interperiodica</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="2012-11-01">2012-11-01</date><biblScope unit="volume">38</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="565">565</biblScope><biblScope unit="page" to="577">577</biblScope></imprint><idno type="ISSN">1068-1620</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1068-1620</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>cytotoxins</term><term>diphtheria toxin</term><term>fragments and domains of diphtheria toxin</term><term>heparin-binding epidermal growth factor-like growth factor (HB-EGF)</term><term>recombinant proteins</term><term>vaccines</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Diphtheria toxin (DT) is a unique bacterial protein which consists of three domains with various biological functions. Using genetic engineering for the creation of various recombinant constructions of DT with definite features, it is possible to create unique tools for cellular biology and toxins with efficient and selective action on certain populations of cells. The review highlights the structural and functional aspects of the DT molecule, its fragments and domains, as well as the major areas of application of its recombinant derivatives. In particular, the perspectives for practical use of recombinant DT derivatives are discussed for creating immunobiological preparations, cytotoxins, blockers of the heparin-binding epidermal growth factor-like growth factor (HB-EGF), protein constructions for direct delivery of substances into the cell, and also the possibility to use DT recombinant derivatives for therapy and prevention of a number of diseases.</div></front></TEI><affiliations><list><country><li>Ukraine</li></country></list><tree><country name="Ukraine"><noRegion><name sortKey="Romaniuk, S I" sort="Romaniuk, S I" uniqKey="Romaniuk S" first="S. I." last="Romaniuk">S. I. Romaniuk</name></noRegion><name sortKey="Kolybo, D V" sort="Kolybo, D V" uniqKey="Kolybo D" first="D. V." last="Kolybo">D. V. Kolybo</name><name sortKey="Komisarenko, S V" sort="Komisarenko, S V" uniqKey="Komisarenko S" first="S. V." last="Komisarenko">S. V. Komisarenko</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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